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Otago HSFY chat - archive

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[MedStudentsOnline.com.au] Otago HSFY chat - archive
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Because the world would be a vastly nicer place without the type of people who make money off of unsubstantial claims and the desperation of others.
 
Can anyone clarify what the HUBS slides from Friday's lecture mean about Isotype switching from B-cells being "independent of the 'generation of diversity'"?
 
alice said:
Can anyone clarify what the HUBS slides from Friday's lecture mean about Isotype switching from B-cells being "independent of the 'generation of diversity'"?
Click to expand...

The generation of diversity is about the receptors themselves, the things which recognize the foreign things. The isotypes are the things like IgE/IgM/IgG etc, they are the types of antibodies.
 
Isotype switching occurs after the generation of diversity. i.e. they're two separate processes.

Generation of diversity = process where genes are arranged to form a specialised receptor.
Isotype switching = Change of 'classes' pretty much.
 
I think we only need to know that occurs and highlight what changes, not the actual process of it? O.o


BTW, 1 more post till hatbox Wongtong!!! :D
 
+1, they never explained the mechanism for the isotype changing. I guess they just fly around and stuff, god knows! Hahah
 
Yeah you guys have got it. You should know how generation of diversity happens though (random splicing etc). But just keep in mind that the isotype doesn't always have to stay the same, and the cell can casually decide to change it without any effect on the specificity of the antibody. That is what they mean by "independent of the generation of diversity.
 
HUBs terms test results came out and after about an hour were taken away again? Odd for them to come out on a Sunday.
 
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